theoretical comparability or divergence
Do family-design and case-control GWASs arrive at the same answers? Any papers discussing actual/theoretical comparability or divergence?
For diseases that are heritable, unaffected parents in a family-based design seem like they might have a higher SNP-mediated burden for disease as compare with a control randomly drawn from the relevant ancestral population. In fact, some parents may have a mild form of the phenotype.