Statistical Significance of difference

Which statistical test should be used to study significance of difference

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You need a lot more data to even consider testing a hypothesis about  differences between drugs.  Additional factors to consider are whether the 2 drugs are given to different people, or if each person got both drugs, and if so, whether in random sequence. You should consult a statistician to help you figure out how many subjects you would need to detect a clinically significant degree of difference.

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