sample size for clinical research

How to calculate sample size for clinical research?

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1. I do a clinical research; let’s say clinical outcomes of a surgical procedure. I have total number of operated patients are 50 in a particular time (let’s say -2014-2016) and I want to measure the postoperative outcome of that patients. How can I calculate a required sample size?

2. In a comparative study, I want to compare the postoperative outcome of a surgical procedure in two different groups of patients who underwent that particular surgical procedure in a particular time period (Let’s say between 2014-2016), Group A has total cases 50 and B also has 50. Now I want to compare the clinical outcomes of improvement of 2 groups of patients. How can I calculate a required sample size?

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