Interaction of Gene Defects
Is anyone studying genetic disease that involves the interaction of more than one gene defect?
a certain combination of variants in these genes plus prenatal maternal smoking greatly increased the chance for a severe form of ADHD. I think it can be tricky to study interactions among multiple genes at once due to power issues, but if you have a plausible hypothesis regarding why there might be a gene-gene interaction, it can be useful to investigate the possibility using that small set of genes. In the case of DAT, DRD4, and CHRNA4 genes, they all have potential to interact to influence dopamine neurotransmission, and the exposure to nicotine could also affect this since binding of nicotine to neural nicotinic acetylcholine receptors can affect the amount of dopamine released.
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