Effects of DNA Mutation and Mapping

1. Can the DNA mutations that do not affect the phenotype be used as the markers to develop human genetic maps?
2. Can the human genetic maps be developed based on DNA mutations that affect phenotype?
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1. a genetic marker (without any functional effect on phenotype) is considered as a good marker if it is in linkage disequilibrium with several (many) polymorphisms/DNA mutations….some of them may be involved in a particular phenotype.
2. If a polymorphism is functional and could affect some phenotypes, it can be used in a genome wide association study; if there is an association between this polymorphism and a phenotype, this polymorphism may be causal. Also, such polymorphisms can be used.

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